t(1;3)(p36;q21) in acute nonlymphocytic leukemia: a new cytogenetic-clinicopathologic association.

Serum lactic dehydrogenase isoenzyme pattern in childhood lymphoblastic leukemia.

8. Bboomfield CD, Garson OM, Volin L, Knuutila 5, de Ia Chapelle A: t(l;3)(p36;q2l) in acute nonlymphocytic leukemia: A new cytogenetic-clinicopathologic association. Blood 66:1409, 1985 9. Viguie F, Marie J-P, Poler F, Bernadou A: Three cases of preleukemic myelodysplastic disorders with the same translocation t(l;3). Cancer Genet Cytogenet 19:213, 1986 10. Atichartakarn V, Punyammalee B, Wong...

A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the MDS1/EVI1 gene and is transcriptionally activated in t(1;3)(p36;q21)-positive leukemia cells.

The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), which is frequently characterized by trilineage dysplasia, in particular dysmegakaryocytopoiesis, and poor prognosis. Previously, the breakpoint cluster region (BCR) at 3q21 was identified within a 60-kilobase (kb) region centromeric to the BCR of 3q21q26 syndrome ...

A new translocation, t(1;3) (p36;q21), in myelodysplastic disorders.

t(1;3)(p36;p21): presentation of a patient with MDS/AML (M2) and review of the literature.

t(1;3)(p36;p21) is a recurrent reciprocal translocation found in a subset of myelodysplastic syndrome (MDS)/acute myelogenous leukemia (AML) characterized by trilineage dysplasia, especially dysmegakaryopoiesis and poor prognosis. In the literature, some authors have suggested that this recurrent translocation is closely associated with prior chemotherapy including alkylating agents in various ...

A novel EVI1 gene family, MEL1, lacking a PR domain (MEL1S) is expressed mainly in t(1;3)(p36;q21)-positive AML and blocks G-CSF-induced myeloid differentiation.

We have identified a novel gene MEL1 (MDS1/EVI1-like gene 1) encoding a zinc finger protein near the breakpoint of t(1; 3)(p36;q21)-positive human acute myeloid leukemia (AML) cells. Here, we studied the structure, expression pattern, and function of MEL1 in leukemia cells. In this study, we have identified 3 transcription start sites, 1 in exon 1 and 2 in exon 2, and 2 kinds of translation pro...